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KMID : 0388019930040040110
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Korean Journal Gynecologic Oncology and Colposcopy
1993 Volume.4 No. 4 p.110 ~ p.117
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DNA Analysis of Hydatidiform Mole by Flow Cytometry and Its Relation to the Prognosis
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Abstract
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Flow cytometric analysis was performed to investigate any relationship between DNA content and clinical outcome in 32 complete hydatidiform moles(CHMs) and 12 partial hydatidiform moles(PHMs). Twenty three and nine of the 32 CHMs were diploid and
aneuploid moles, respectively. Of these 23 diploid CHMs, eight (34.8%) regressed spontaneously and 15 (65.2%) progressed to persistent gestational trophoblastic disease (PGTD). Among nine aneuploid CHMs studied, six (66.7%) underwent spontaneous
regression and three (33.3%) required treatment for persistent GTD. The twelve PHMs consisted of 9 diploid and 3 andeuploid moles. Three of the nine diploid moles (33.3%) remitted completely, while the remaining 6(66.7%) progressed to PGTD. All
aneuploid PIMs underwent spontaneous remission. The S―phase of cell cycle in the CHMs studied was more frequent in those that progressed to persistent GTDs G0/G1 was more frequent in those that remitted spontaneously. The PHMs studied failed to
show
any significant relationship between the phases of cell and disease prognosis.
Our results suggest the potential use of DNA ploidy and cell cycle analysis in predicting clinical outcome and thus in selecting cases for prophylactic chemotherapy.
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KEYWORD
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